BMP1

Across TCGA cell cohorts, BMP1 mutation is significantly associated with the mutation status of many other genes, with 4,360 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BMP1-associated genes across cancer lineages are NAV1, GTF3C1, and CHPF2. Each is linked with BMP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BMP1-to-partner and partner-to-BMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAV1 grouped by BMP1-low versus BMP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP1→partner) and Y-score (partner→BMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NAV1 →	+2.845	+3.209	.003	.003	1	5
BLOOD_Leukemia	GTF3C1 →	+2.466	+3.281	.001	.001	1	4
BLOOD_Leukemia	CHPF2 →	+4.430	+3.823	.001	.001	1	4
OVARY	EHMT1 →	+4.415	+4.977	.007	.007	1	4
BLOOD_Leukemia	MYH6 →	+3.108	+4.326	<.001	<.001	1	4
BLOOD_Leukemia	PI4KA →	+2.523	+2.960	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,360 associations by consensus.

NAV1 by BMP1 expression — BLOOD_Leukemia

Explore this box plot interactively →