BLOC1S1

Across TCGA patient cohorts, BLOC1S1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible BLOC1S1-associated genes across cancer lineages are MIR1294, OR51B3P, and RN7SL177P. Each is linked with BLOC1S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BLOC1S1-to-partner and partner-to-BLOC1S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1294 grouped by BLOC1S1-low versus BLOC1S1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLOC1S1→partner) and Y-score (partner→BLOC1S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1294 →	+0.735	+5.031	<.001	.009	3	1
UCEC	OR51B3P →	+0.114	+5.420	.005	.005	3	1
UCEC	RN7SL177P →	+0.310	+5.484	.003	.005	3	1
UCEC	RN7SKP12 →	+0.767	+5.551	<.001	.004	3	1
UCEC	RNU2-19P →	+1.080	+6.123	<.001	.002	3	1
UCEC	MIR4698 →	+0.827	+5.031	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MIR1294 by BLOC1S1 expression — UCEC

Explore this box plot interactively →