BLOC1S1

Across TCGA pan-cancer cohorts, BLOC1S1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated BLOC1S1 data layer compared with 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher BLOC1S1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BLOC1S1 expression acts as an unfavorable survival marker, although some lineages such as OV and MESO show a favorable association.

UVM, LAML, and OV are the cancer types where BLOC1S1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.453	0.856	<.001	68	view →
LAML	DFS	Median	All	0.248	0.496	<.001	50	view →
OV	OS	Median	All	0.891	0.787	<.001	44	view →
KIRC	OS	Tertile	All	0.831	0.903	.001	43	view →
LGG	OS	Median	All	0.352	0.513	<.001	39	view →
UCS	DFS	Median	IV	0.367	0.952	.001	36	view →
LUAD	DFS	Quartile	II,III,IV	0.314	0.651	.002	33	view →
READ	OS	Median	II,III,IV	0.311	0.799	.002	26	view →
KICH	DFS	Quartile	III,IV	0.162	1.000	.004	24	view →
MESO	DFS	Median	II,III,IV	0.505	0.302	.003	23	view →
CESC	OS	Quartile	All	0.938	0.719	<.001	22	view →
ESCA	OS	Median	III,IV	0.311	0.567	.019	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

BLOC1S1–UVM (DFS)

Open the UVM breakdown →