BLNK

Across TCGA patient cohorts, BLNK mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLNK-associated genes across cancer lineages are FASN, mTOR_pS2448, and Paxillin. Each is linked with BLNK in more than 1 cancer types. Because this analysis shows association rather than direction, both BLNK-to-partner and partner-to-BLNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by BLNK-low versus BLNK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLNK→partner) and Y-score (partner→BLNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.533	+1.906	<.001	.016	3	2
UCEC	mTOR_pS2448 →	-0.165	-1.906	.006	.016	3	2
UCEC	Paxillin →	+0.230	+2.469	.027	.010	3	2
UCEC	Src_pY527 →	-0.392	-2.449	.023	.019	3	2
UCEC	TFRC →	+0.813	+3.087	<.001	<.001	3	2
UCEC	ASNS →	+0.393	+2.321	.006	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

FASN by BLNK expression — UCEC

Explore this box plot interactively →