Across TCGA patient cohorts, BLM protein abundance is significantly associated with the RNA expression of many other genes, with 11,661 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BLM-associated genes across cancer lineages are CEP152, OIP5, and ASF1B. Each is linked with BLM in more than 5 cancer types. Because this analysis shows association rather than direction, both BLM-to-partner and partner-to-BLM results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLM→partner) and Y-score (partner→BLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CEP152 →	+0.644	+0.474	<.001	<.001	3	6
HNSC	OIP5 →	+1.026	+0.828	<.001	<.001	3	6
HNSC	ASF1B →	+1.130	+0.490	.001	.009	3	6
GBM	EZH2 →	+0.992	+0.705	<.001	.001	3	6
HNSC	RAD51AP1 →	+1.143	+0.539	.001	.008	3	6
HNSC	LMNB1 →	+0.976	+0.618	.008	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,661 associations by consensus.

Exploration

BLM survival (RNA) · tumor vs normal (RNA) · all BLM data types