BLK

Across TCGA patient cohorts, BLK mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLK-associated genes across cancer lineages are eEF2, PCNA, and Shc_pY317. Each is linked with BLK in more than 2 cancer types. Because this analysis shows association rather than direction, both BLK-to-partner and partner-to-BLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by BLK-low versus BLK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLK→partner) and Y-score (partner→BLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.365	+2.000	.007	.030	3	2
UCEC	PCNA →	+0.262	+1.678	.001	.023	3	2
UCEC	Shc_pY317 →	-0.176	-2.222	.002	.010	3	2
SKCM	Notch1 →	-0.194	-3.157	.029	.018	3	2
SKCM	Rictor_pT1135 →	-0.162	-2.567	.023	.011	2	3
SKCM	Rictor →	-0.308	-2.584	.039	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eEF2 by BLK expression — UCEC

Explore this box plot interactively →