BLK

Across TCGA cell cohorts, BLK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,643 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BLK-associated GO terms across cancer lineages are Regulation of focal adhesion assembly, Regulation of cell-substrate junction assembly, and Regulation of mitophagy. Each is linked with BLK in more than 5 cancer types. Because this analysis shows association rather than direction, both BLK-to-partner and partner-to-BLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of focal adhesion assembly grouped by BLK-low versus BLK-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BLK→partner) and Y-score (partner→BLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of focal adhesion assembly →	+0.138	+0.145	<.001	<.001	3	6
OESOPHAGUS	Regulation of cell-substrate junction assembly →	+0.138	+0.145	<.001	<.001	3	6
SKIN	Regulation of mitophagy →	+0.072	+0.415	.003	.003	3	6
SKIN	Regulation of autophagy of mitochondrion →	+0.081	+0.442	<.001	.001	3	6
LARGE_INTESTINE	Negative regulation of calcium ion export across plasma membrane →	+0.059	+0.052	<.001	.002	3	6
PANCREAS	Positive regulation of cell cycle checkpoint →	+0.084	+0.217	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,643 associations by consensus.

Regulation of focal adhesion assembly by BLK expression — OESOPHAGUS

Explore this box plot interactively →