BLACAT1

Across TCGA pan-cancer cohorts, BLACAT1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of BLACAT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BLACAT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BLACAT1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where BLACAT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BLACAT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.340	<.001	12	view →
COAD	Female	III,IV	+2.544	<.001	11	view →
THCA	Male	III,IV	+1.224	<.001	10	view →
LUAD	Female	All	+1.706	<.001	9	view →
KICH	Male	All	−1.351	<.001	9	view →
KIRC	All	II,III,IV	−0.659	<.001	9	view →
LUSC	Male	All	+1.513	<.001	7	view →
BLCA	All	All	+1.292	<.001	6	view →
KIRP	Male	All	+1.129	<.001	6	view →
BRCA	All	III,IV	−0.579	<.001	6	view →
STAD	Male	All	+1.444	<.001	5	view →
ESCA	Male	All	+2.758	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

BLACAT1–HNSC

Open the HNSC breakdown →