BIRC8

Across TCGA cell cohorts, BIRC8 RNA expression is significantly associated with the mutation status of many other genes, with 23 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BIRC8-associated genes across cancer lineages are AAAS, WSCD1, and CTR9. Each is linked with BIRC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIRC8-to-partner and partner-to-BIRC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AAAS grouped by BIRC8-low versus BIRC8-high in BLOOD_Lymphoma.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC8→partner) and Y-score (partner→BIRC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AAAS →	+3.925	+0.002	.006	<.001	3	1
LUNG_NSCLC_LUSC	WSCD1 →	+4.643	+0.016	.008	<.001	3	1
LUNG_NSCLC_LUSC	CTR9 →	+4.643	+0.016	.008	<.001	3	1
LUNG_NSCLC_LUSC	PAG1 →	+4.643	+0.016	.008	<.001	3	1
LUNG_NSCLC_LUSC	N4BP2 →	+4.643	+0.016	.008	<.001	3	1
LUNG_NSCLC_LUSC	PIAS4 →	+4.643	+0.016	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

AAAS by BIRC8 expression — BLOOD_Lymphoma

Explore this box plot interactively →