BIRC7

Across TCGA patient cohorts, BIRC7 mutation is significantly associated with the RNA expression of many other genes, with 322 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIRC7-associated genes across cancer lineages are RNU7-176P, NKAIN1P2, and RNA5SP412. Each is linked with BIRC7 in more than 2 cancer types. Because this analysis shows association rather than direction, both BIRC7-to-partner and partner-to-BIRC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-176P grouped by BIRC7-low versus BIRC7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC7→partner) and Y-score (partner→BIRC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU7-176P →	+0.537	+7.741	<.001	.009	3	3
SKCM	NKAIN1P2 →	+0.138	+6.485	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.870	+2.744	<.001	.001	3	2
SKCM	RNA5SP72 →	+0.245	+5.080	<.001	.004	3	2
SKCM	POTEF-AS1 →	+0.090	+6.452	<.001	<.001	3	2
SKCM	LINC01280 →	+0.170	+4.268	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 322 associations by consensus.

RNU7-176P by BIRC7 expression — COAD

Explore this box plot interactively →