BIRC6

Across TCGA patient cohorts, BIRC6 mutation is significantly associated with the RNA expression of many other genes, with 7,004 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIRC6-associated genes across cancer lineages are UQCRH, NRIP2, and GOT1. Each is linked with BIRC6 in more than 5 cancer types. Because this analysis shows association rather than direction, both BIRC6-to-partner and partner-to-BIRC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCRH grouped by BIRC6-low versus BIRC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC6→partner) and Y-score (partner→BIRC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UQCRH →	+0.652	+1.048	<.001	<.001	3	6
HNSC	NRIP2 →	-0.451	-2.883	.003	.002	2	6
COAD	GOT1 →	+0.395	+3.013	<.001	<.001	3	5
COAD	GTF2H2C →	+0.233	+2.754	<.001	.002	3	5
COAD	SAR1B →	+0.399	+2.961	<.001	<.001	3	5
UCEC	SFXN1 →	+0.469	+1.465	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,004 associations by consensus.

UQCRH by BIRC6 expression — UCEC

Explore this box plot interactively →