BIRC6

Across TCGA patient cohorts, BIRC6 mutation is significantly associated with the total protein of many other genes, with 111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIRC6-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and GAPDH. Each is linked with BIRC6 in more than 6 cancer types. Because this analysis shows association rather than direction, both BIRC6-to-partner and partner-to-BIRC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by BIRC6-low versus BIRC6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC6→partner) and Y-score (partner→BIRC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.105	+3.807	<.001	<.001	3	7
COAD	PCNA →	+0.200	+2.128	.011	.009	3	6
KIRC	GAPDH →	+0.973	+2.813	.019	.037	3	5
UCEC	Cyclin-B1 →	+0.579	+1.201	<.001	<.001	3	5
COAD	ATM →	-0.659	-2.584	<.001	<.001	3	5
UCEC	TFRC →	+0.505	+1.306	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 111 associations by consensus.

Caspase-7-cleavedD198 by BIRC6 expression — COAD

Explore this box plot interactively →