BIRC6

Across TCGA cell cohorts, BIRC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,651 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BIRC6-associated GO terms across cancer lineages are Positive regulation of mRNA metabolic process, Heterochromatin formation, and Phosphatidylinositol-3-phosphate biosynthetic process. Each is linked with BIRC6 in more than 16 cancer types. Because this analysis shows association rather than direction, both BIRC6-to-partner and partner-to-BIRC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mRNA metabolic process grouped by BIRC6-low versus BIRC6-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC6→partner) and Y-score (partner→BIRC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of mRNA metabolic process →	+0.079	+0.931	<.001	<.001	3	17
SOFT_TISSUE	Heterochromatin formation →	+0.076	+0.833	<.001	<.001	3	17
LUNG_SCLC	Phosphatidylinositol-3-phosphate biosynthetic process →	+0.084	+0.550	<.001	<.001	3	17
SOFT_TISSUE	Negative regulation of gene expression, epigenetic →	+0.073	+0.978	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Stress granule assembly →	+0.141	+0.859	<.001	<.001	3	17
OVARY	Heterochromatin organization →	+0.059	+0.485	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,651 associations by consensus.

Positive regulation of mRNA metabolic process by BIRC6 expression — SOFT_TISSUE

Explore this box plot interactively →