BIRC5

Across TCGA patient cohorts, BIRC5 mutation is significantly associated with the RNA expression of many other genes, with 275 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIRC5-associated genes across cancer lineages are RNU6-178P, RNU6-218P, and RN7SL769P. Each is linked with BIRC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIRC5-to-partner and partner-to-BIRC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-178P grouped by BIRC5-low versus BIRC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC5→partner) and Y-score (partner→BIRC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-178P →	+0.759	+3.026	<.001	.001	3	2
UCEC	RNU6-218P →	+0.526	+2.219	.001	.005	3	2
SKCM	RN7SL769P →	+0.151	+4.730	.005	.003	3	1
UCEC	KMT5AP1 →	+0.348	+3.254	<.001	.008	3	1
SKCM	SPRYD7P1 →	+0.062	+4.867	<.001	.005	3	1
SKCM	KATNBL1P3 →	+0.067	+4.440	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 275 associations by consensus.

RNU6-178P by BIRC5 expression — UCEC

Explore this box plot interactively →