BIRC3

Across TCGA patient cohorts, BIRC3 protein abundance is significantly associated with the RNA expression of many other genes, with 7,788 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BIRC3-associated genes across cancer lineages are XCR1, TLR10, and APOBEC3H. Each is linked with BIRC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both BIRC3-to-partner and partner-to-BIRC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BIRC3 versus XCR1 in UCEC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC3→partner) and Y-score (partner→BIRC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XCR1 →	+0.483	+1.268	<.001	<.001	3	3
UCEC	TLR10 →	+1.085	+1.148	<.001	.002	3	3
CCRCC	APOBEC3H →	+0.753	+0.504	.005	.006	3	3
LSCC	TNFSF13B →	+0.853	+0.796	<.001	<.001	3	3
LSCC	CD37 →	+0.606	+0.527	<.001	<.001	3	3
LSCC	CD4 →	+0.633	+0.645	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,788 associations by consensus.

BIRC3 vs XCR1 — UCEC

Explore this scatter interactively →