BIRC3

Across TCGA pan-cancer cohorts, BIRC3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated BIRC3 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher BIRC3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated BIRC3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, KIRP, and HNSC are the cancer types where BIRC3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.419	0.250	<.001	133	view →
KIRP	OS	Tertile	All	0.593	0.751	<.001	121	view →
HNSC	DFS	Tertile	III,IV	0.510	0.269	<.001	113	view →
UVM	OS	Quartile	All	0.385	0.713	.004	60	view →
BRCA	DFS	Quartile	All	0.603	0.471	<.001	46	view →
LGG	OS	Median	All	0.744	0.873	<.001	40	view →
READ	OS	Median	II,III,IV	0.917	0.429	.001	32	view →
GBM	DFS	Quartile	All	0.145	0.428	.002	30	view →
UCS	OS	Median	IV	0.752	0.404	.013	30	view →
LUAD	OS	Quartile	All	0.190	0.410	.004	15	view →
SARC	OS	Tertile	All	0.882	0.753	.002	15	view →
LIHC	OS	Median	All	0.844	0.689	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

BIRC3–SKCM (OS)

Open the SKCM breakdown →