BIRC3

Across TCGA patient cohorts, BIRC3 mutation is significantly associated with the RNA expression of many other genes, with 574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIRC3-associated genes across cancer lineages are TRIM53CP, TIMM9P1, and MTND5P35. Each is linked with BIRC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both BIRC3-to-partner and partner-to-BIRC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM53CP grouped by BIRC3-low versus BIRC3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC3→partner) and Y-score (partner→BIRC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRIM53CP →	+0.057	+4.962	<.001	.003	3	3
SKCM	TIMM9P1 →	+0.104	+2.657	<.001	.006	3	2
BLCA	MTND5P35 →	+0.031	+5.788	<.001	.003	3	2
SKCM	SKA2 →	+0.611	+3.487	.008	.002	3	2
SKCM	CDCA2 →	+0.954	+3.706	<.001	<.001	3	2
SKCM	RPL17-C18orf32 →	+0.120	+3.104	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 574 associations by consensus.

TRIM53CP by BIRC3 expression — COAD

Explore this box plot interactively →