BIRC3

Across TCGA cell cohorts, BIRC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,314 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible BIRC3-associated GO terms across cancer lineages are Canonical NF-kappaB signal transduction, Response to tumor necrosis factor, and Cellular response to tumor necrosis factor. Each is linked with BIRC3 in more than 16 cancer types. Because this analysis shows association rather than direction, both BIRC3-to-partner and partner-to-BIRC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Canonical NF-kappaB signal transduction grouped by BIRC3-low versus BIRC3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC3→partner) and Y-score (partner→BIRC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Canonical NF-kappaB signal transduction →	+0.148	+3.092	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Response to tumor necrosis factor →	+0.087	+3.051	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Cellular response to tumor necrosis factor →	+0.102	+3.232	.002	<.001	3	16
OVARY	Non-canonical NF-kappaB signal transduction →	+0.128	+2.770	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of protein K48-linked ubiquitination →	+0.176	+2.392	<.001	.007	3	16
SOFT_TISSUE	Antigen processing and presentation of endogenous peptide antigen →	+0.228	+2.041	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,314 associations by consensus.

Canonical NF-kappaB signal transduction by BIRC3 expression — LIVER

Explore this box plot interactively →