BIN2

Across TCGA cell cohorts, BIN2 mutation is significantly associated with the mutation status of many other genes, with 3,050 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BIN2-associated genes across cancer lineages are MAST1, CLDN14, and FYCO1. Each is linked with BIN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both BIN2-to-partner and partner-to-BIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAST1 grouped by BIN2-low versus BIN2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN2→partner) and Y-score (partner→BIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAST1 →	+2.860	+4.640	.001	.001	1	4
SKIN	CLDN14 →	+5.824	+5.824	.002	.002	1	4
BLOOD_Leukemia	FYCO1 →	+2.823	+3.665	.008	.008	1	4
SKIN	TUBB3 →	+4.239	+5.053	.007	.007	1	4
SKIN	HAUS5 →	+4.824	+5.392	.004	.004	1	4
SOFT_TISSUE	PCDHA1 →	+5.066	+4.502	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,050 associations by consensus.

MAST1 by BIN2 expression — BLOOD_Leukemia

Explore this box plot interactively →