BIK

Across TCGA patient cohorts, BIK mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIK-associated genes across cancer lineages are ACC1 and HER3. Each is linked with BIK in more than 1 cancer types. Because this analysis shows association rather than direction, both BIK-to-partner and partner-to-BIK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by BIK-low versus BIK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIK→partner) and Y-score (partner→BIK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.465	+3.000	.026	.037	1	1
UCEC	HER3 →	-0.339	-2.986	.032	.037	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

ACC1 by BIK expression — UCEC

Explore this box plot interactively →