BIK

Across TCGA pan-cancer cohorts, BIK RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of BIK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BIK RNA is repressed in tumor relative to normal tissue. In most cancer types BIK is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, LUSC, and LUAD are the cancer types where BIK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BIK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−1.748	<.001	12	view →
LUSC	Female	II,III,IV	+2.791	<.001	9	view →
LUAD	Male	III,IV	+1.910	<.001	9	view →
BRCA	All	III,IV	+1.704	<.001	8	view →
HNSC	Male	III,IV	+1.828	<.001	7	view →
LIHC	All	II,III,IV	+1.185	<.001	7	view →
KIRP	All	All	−0.701	<.001	7	view →
COAD	All	II,III,IV	+0.864	<.001	6	view →
THCA	All	All	−0.536	<.001	5	view →
STAD	Male	All	+2.165	<.001	4	view →
ESCA	All	All	+1.636	.002	4	view →
PAAD	All	All	+1.147	.019	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

BIK–KIRC

Open the KIRC breakdown →