BICRAL

Across TCGA pan-cancer cohorts, BICRAL mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated BICRAL data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher BICRAL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BICRAL expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where BICRAL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.826	0.579	.003	22	view →
HNSC	DFS	Median	All	1.000	0.885	.012	6	view →
PDAC	DFS	Median	III,IV	0.515	0.819	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

BICRAL–LSCC (DFS)

Open the LSCC breakdown →