BICRAL

Across TCGA pan-cancer cohorts, BICRAL RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of BICRAL’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where BICRAL RNA is repressed in tumor relative to normal tissue. In most cancer types BICRAL is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BLCA are the cancer types where BICRAL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BICRAL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.682	<.001	8	view →
KICH	Female	All	−1.473	<.001	7	view →
BLCA	Male	IV	−1.174	.001	7	view →
LIHC	All	II,III,IV	+0.626	<.001	7	view →
UCEC	All	All	−1.316	<.001	6	view →
LUSC	Male	All	−0.479	<.001	6	view →
COAD	Female	All	−0.439	.008	4	view →
BRCA	Female	All	−0.305	<.001	4	view →
CHOL	All	All	+1.843	<.001	3	view →
STAD	Male	II,III,IV	+0.636	.043	1	view →
KIRC	All	All	+0.222	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

BICRAL–THCA

Open the THCA breakdown →