BICRAL

Across TCGA patient cohorts, BICRAL mutation is significantly associated with the RNA expression of many other genes, with 2,480 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BICRAL-associated genes across cancer lineages are HMGB1P17, UBTFL11, and ZWINT. Each is linked with BICRAL in more than 2 cancer types. Because this analysis shows association rather than direction, both BICRAL-to-partner and partner-to-BICRAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P17 grouped by BICRAL-low versus BICRAL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BICRAL→partner) and Y-score (partner→BICRAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGB1P17 →	+0.131	+1.615	<.001	.001	3	3
COAD	UBTFL11 →	+0.034	+3.736	.002	.005	3	3
UCEC	ZWINT →	+0.602	+2.081	.001	.001	3	3
UCEC	E2F1 →	+0.770	+2.556	<.001	<.001	3	3
UCEC	DOC2B →	-0.802	-1.826	.001	.007	3	2
UCEC	PRSS53 →	+0.309	+2.821	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,480 associations by consensus.

HMGB1P17 by BICRAL expression — UCEC

Explore this box plot interactively →