BICRAL

Across TCGA cell cohorts, BICRAL mutation is significantly associated with the RNA expression of many other genes, with 87 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BICRAL-associated genes across cancer lineages are BHLHE23, MS4A4A, and GML. Each is linked with BICRAL in more than 1 cancer types. Because this analysis shows association rather than direction, both BICRAL-to-partner and partner-to-BICRAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BHLHE23 grouped by BICRAL-low versus BICRAL-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BICRAL→partner) and Y-score (partner→BICRAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BHLHE23 →	+0.044	+3.362	<.001	.007	3	2
SKIN	MS4A4A →	+0.084	+3.758	<.001	.004	3	2
BLOOD_Leukemia	GML →	+0.056	+2.982	<.001	.007	3	2
BLOOD_Leukemia	NKX2-6 →	+0.278	+3.786	<.001	.002	3	2
BLOOD_Leukemia	NPSR1 →	+0.022	+2.982	<.001	.007	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

BHLHE23 by BICRAL expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →