BICRA-AS1

Across TCGA pan-cancer cohorts, BICRA-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of BICRA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BICRA-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types BICRA-AS1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where BICRA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BICRA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.494	<.001	11	view →
KICH	All	All	−0.747	<.001	6	view →
KIRP	Male	All	−0.503	<.001	6	view →
LUSC	All	All	−0.188	.001	5	view →
LUAD	All	III,IV	−0.290	.003	3	view →
BRCA	All	All	+0.221	.019	3	view →
STAD	All	II,III,IV	+0.339	.029	2	view →
THCA	All	All	−0.051	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

BICRA-AS1–KIRC

Open the KIRC breakdown →