BHMT

Across TCGA cell cohorts, BHMT mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BHMT-associated genes across cancer lineages are C3orf56, RAI1, and FAM149A. Each is linked with BHMT in more than 1 cancer types. Because this analysis shows association rather than direction, both BHMT-to-partner and partner-to-BHMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C3orf56 grouped by BHMT-low versus BHMT-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHMT→partner) and Y-score (partner→BHMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C3orf56 →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	RAI1 →	+0.957	+3.064	.001	.009	3	1
LARGE_INTESTINE	FAM149A →	+1.539	+3.067	<.001	.009	3	1
LARGE_INTESTINE	ALDH6A1 →	+1.138	+3.064	<.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	GALR3 →	+0.136	+3.602	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

C3orf56 by BHMT expression — SKIN

Explore this box plot interactively →