BHLHE41

Across TCGA pan-cancer cohorts, BHLHE41 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of BHLHE41’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where BHLHE41 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types BHLHE41 is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

CCRCC and LSCC are the cancer types where BHLHE41 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BHLHE41 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	+1.524	.001	8	view →
LSCC	All	All	−0.591	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

BHLHE41–CCRCC

Open the CCRCC breakdown →