BHLHE41

Across TCGA pan-cancer cohorts, BHLHE41 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated BHLHE41 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher BHLHE41 RNA is associated with better overall survival. In most high-consensus cancer types, elevated BHLHE41 expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

BLCA, BRCA, and DLBC are the cancer types where BHLHE41 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.677	0.538	<.001	86	view →
BRCA	DFS	Quartile	III,IV	0.671	0.427	.002	59	view →
DLBC	DFS	Median	All	1.000	0.590	.005	41	view →
UVM	DFS	Median	II,III,IV	0.335	0.618	.009	22	view →
HNSC	DFS	Median	III,IV	0.431	0.206	.002	21	view →
CHOL	DFS	Tertile	II,III,IV	0.704	0.114	.007	20	view →
CESC	OS	Median	II,III,IV	0.645	0.428	.014	20	view →
THCA	OS	Tertile	III,IV	1.000	0.705	.003	18	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
MESO	DFS	Tertile	All	0.375	0.666	.019	15	view →
LUAD	DFS	Median	All	0.831	0.748	.006	15	view →
LGG	OS	Median	All	0.346	0.530	.002	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

BHLHE41–BLCA (OS)

Open the BLCA breakdown →