BHLHE41

Across TCGA patient cohorts, BHLHE41 mutation is significantly associated with the RNA expression of many other genes, with 927 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BHLHE41-associated genes across cancer lineages are RNA5SP418, RNA5SP421, and RNA5SP415. Each is linked with BHLHE41 in more than 1 cancer types. Because this analysis shows association rather than direction, both BHLHE41-to-partner and partner-to-BHLHE41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP418 grouped by BHLHE41-low versus BHLHE41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHE41→partner) and Y-score (partner→BHLHE41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP418 →	+1.168	+2.500	<.001	.001	3	2
UCEC	RNA5SP421 →	+1.147	+2.603	<.001	<.001	3	2
UCEC	RNA5SP415 →	+0.900	+3.126	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.870	+2.604	<.001	<.001	3	2
COAD	TEX44 →	+0.192	+4.295	<.001	.008	3	1
UCEC	MYO19 →	+0.556	+3.346	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 927 associations by consensus.

RNA5SP418 by BHLHE41 expression — UCEC

Explore this box plot interactively →