BHLHE41

Across TCGA patient cohorts, BHLHE41 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BHLHE41-associated genes across cancer lineages are EGFR_pY1068, IGFBP2, and INPP4B. Each is linked with BHLHE41 in more than 1 cancer types. Because this analysis shows association rather than direction, both BHLHE41-to-partner and partner-to-BHLHE41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by BHLHE41-low versus BHLHE41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHE41→partner) and Y-score (partner→BHLHE41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.242	-2.000	.032	.032	3	1
UCEC	IGFBP2 →	-0.808	-2.700	.005	.006	3	1
UCEC	INPP4B →	-0.331	-3.169	.023	.018	3	1
UCEC	MEK1 →	+0.461	+2.700	.005	.006	3	1
UCEC	p21 →	+0.182	+2.700	.036	.006	3	1
UCEC	Rab25 →	-0.507	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by BHLHE41 expression — UCEC

Explore this box plot interactively →