BHLHE40

Across TCGA patient cohorts, BHLHE40 mutation is significantly associated with the RNA expression of many other genes, with 2,100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BHLHE40-associated genes across cancer lineages are KATNBL1P4, LINC00351, and CSGALNACT2P2. Each is linked with BHLHE40 in more than 1 cancer types. Because this analysis shows association rather than direction, both BHLHE40-to-partner and partner-to-BHLHE40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KATNBL1P4 grouped by BHLHE40-low versus BHLHE40-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHE40→partner) and Y-score (partner→BHLHE40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	KATNBL1P4 →	+0.088	+5.018	<.001	.004	3	2
CESC	LINC00351 →	+0.138	+4.786	<.001	.001	3	2
KIRP	CSGALNACT2P2 →	+0.909	+5.628	<.001	.004	3	2
KIRP	EI24P1 →	+0.143	+5.497	<.001	.004	3	2
BLCA	EIF2S2P7 →	+0.032	+4.685	<.001	.007	3	2
BLCA	OR5AN1 →	+0.068	+5.444	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,100 associations by consensus.

KATNBL1P4 by BHLHE40 expression — BLCA

Explore this box plot interactively →