BHLHE40

Across TCGA pan-cancer cohorts, BHLHE40 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated BHLHE40 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher BHLHE40 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated BHLHE40 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

BRCA, PAAD, and LGG are the cancer types where BHLHE40 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Quartile	III,IV	0.964	0.800	<.001	72	view →
PAAD	OS	Median	All	0.384	0.666	<.001	52	view →
LGG	OS	Median	All	0.735	0.884	<.001	49	view →
OV	OS	Median	All	0.276	0.362	.014	30	view →
THCA	OS	Median	II,III,IV	0.832	1.000	.014	28	view →
BLCA	OS	Quartile	All	0.505	0.806	.003	25	view →
LUSC	DFS	Quartile	All	0.505	0.694	.003	24	view →
KIRC	DFS	Tertile	IV	0.393	0.777	.005	20	view →
GBM	OS	Quartile	All	0.192	0.584	<.001	19	view →
KIRP	DFS	Tertile	IV	0.047	0.765	.010	18	view →
UVM	DFS	Median	III,IV	0.207	0.673	.009	16	view →
LUAD	DFS	Tertile	All	0.755	0.858	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

BHLHE40–BRCA (DFS)

Open the BRCA breakdown →