BHLHE40

Across TCGA patient cohorts, BHLHE40 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BHLHE40-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and JNK2. Each is linked with BHLHE40 in more than 1 cancer types. Because this analysis shows association rather than direction, both BHLHE40-to-partner and partner-to-BHLHE40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by BHLHE40-low versus BHLHE40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHE40→partner) and Y-score (partner→BHLHE40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.226	+2.000	.006	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.172	-2.321	.009	.034	3	1
UCEC	JNK2 →	+0.223	+2.348	.004	.018	3	1
UCEC	MEK1 →	+0.439	+2.807	.002	.003	2	2
UCEC	MSH2 →	-0.197	-1.848	.029	.049	3	1
UCEC	Notch1 →	+0.119	+1.584	.032	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

eIF4E by BHLHE40 expression — UCEC

Explore this box plot interactively →