BHLHE40

Across TCGA cell cohorts, BHLHE40 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,267 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible BHLHE40-associated GO terms across cancer lineages are Negative regulation of immune response, Type II interferon-mediated signaling pathway, and Cellular response to chemical stress. Each is linked with BHLHE40 in more than 13 cancer types. Because this analysis shows association rather than direction, both BHLHE40-to-partner and partner-to-BHLHE40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of immune response grouped by BHLHE40-low versus BHLHE40-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHE40→partner) and Y-score (partner→BHLHE40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of immune response →	+0.094	+2.065	<.001	<.001	3	14
OVARY	Type II interferon-mediated signaling pathway →	+0.202	+1.457	<.001	<.001	3	13
LUNG_NSCLC_LUAD	Cellular response to chemical stress →	+0.045	+1.516	<.001	<.001	3	13
SOFT_TISSUE	Viral process →	+0.082	+1.866	<.001	<.001	3	13
BONE	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.132	+2.102	<.001	<.001	3	13
SOFT_TISSUE	Viral life cycle →	+0.080	+2.229	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,267 associations by consensus.

Negative regulation of immune response by BHLHE40 expression — SOFT_TISSUE

Explore this box plot interactively →