Across TCGA pan-cancer cohorts, BGLT3 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of BGLT3’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BGLT3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BGLT3 is over-expressed in tumor.
KIRC are the cancer types where BGLT3 tumor–normal differential expression is most reproducible.