BEX3

Across TCGA pan-cancer cohorts, BEX3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated BEX3 data layer compared with 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher BEX3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BEX3 expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRC show a favorable association.

LUAD, STAD, and HNSC are the cancer types where BEX3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.728	0.844	.001	101	view →
STAD	OS	Tertile	All	0.574	0.755	<.001	75	view →
HNSC	OS	Median	All	0.275	0.498	<.001	74	view →
LGG	DFS	Median	All	0.491	0.320	<.001	42	view →
KIRC	OS	Tertile	All	0.733	0.522	<.001	39	view →
OV	OS	Median	IV	0.498	0.272	.003	32	view →
UCEC	DFS	Tertile	All	0.549	0.783	<.001	26	view →
THCA	DFS	Tertile	All	0.899	0.712	<.001	24	view →
ACC	DFS	Quartile	II,III,IV	0.206	0.784	<.001	23	view →
READ	DFS	Quartile	II,III,IV	0.235	0.818	.008	22	view →
PAAD	DFS	Quartile	All	0.533	0.170	<.001	18	view →
SARC	OS	Tertile	All	0.387	0.612	.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

BEX3–LUAD (DFS)

Open the LUAD breakdown →