BEX3

Across TCGA pan-cancer cohorts, BEX3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of BEX3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BEX3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BEX3 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, THCA, and KIRC are the cancer types where BEX3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BEX3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.713	<.001	12	view →
THCA	All	IV	−1.787	<.001	11	view →
KIRC	Male	II,III,IV	−0.823	<.001	11	view →
KICH	All	All	−2.078	<.001	9	view →
LUAD	All	III,IV	−0.905	<.001	8	view →
CHOL	All	All	+2.431	<.001	5	view →
STAD	All	All	−0.785	.019	4	view →
LIHC	All	All	+0.759	.002	4	view →
KIRP	Male	All	−0.869	<.001	3	view →
BRCA	All	IV	+0.449	.036	2	view →
LUSC	All	All	+0.434	.002	2	view →
PRAD	All	All	−0.360	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

BEX3–HNSC

Open the HNSC breakdown →