BEX2

Across TCGA patient cohorts, BEX2 mutation is significantly associated with the RNA expression of many other genes, with 443 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEX2-associated genes across cancer lineages are IGHV3OR16-8, NOL12, and IGKV1D-13. Each is linked with BEX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEX2-to-partner and partner-to-BEX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHV3OR16-8 grouped by BEX2-low versus BEX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEX2→partner) and Y-score (partner→BEX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHV3OR16-8 →	+0.713	+3.721	.003	<.001	3	1
UCEC	NOL12 →	+0.398	+3.732	.003	<.001	3	1
UCEC	IGKV1D-13 →	+2.177	+3.608	<.001	.001	3	1
UCEC	IGHV4-4 →	+0.974	+2.538	.001	.002	3	1
UCEC	GTSE1-DT →	+0.620	+3.401	<.001	.004	3	1
UCEC	TIMM8B →	+0.442	+3.700	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 443 associations by consensus.

IGHV3OR16-8 by BEX2 expression — UCEC

Explore this box plot interactively →