BET1-AS1

Across TCGA pan-cancer cohorts, BET1-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of BET1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where BET1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types BET1-AS1 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where BET1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BET1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.650	<.001	11	view →
KIRC	All	II,III,IV	+0.287	<.001	10	view →
LIHC	Female	III,IV	+0.440	<.001	7	view →
LUSC	Female	II,III,IV	−0.995	<.001	6	view →
UCEC	All	All	−0.956	<.001	6	view →
BRCA	All	III,IV	−0.658	<.001	6	view →
LUAD	All	III,IV	−0.494	<.001	4	view →
CHOL	All	All	+0.927	<.001	3	view →
HNSC	All	III,IV	+0.264	.012	3	view →
STAD	All	II,III,IV	+0.388	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

BET1-AS1–THCA

Open the THCA breakdown →