BEST4

Across TCGA patient cohorts, BEST4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,161 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible BEST4-associated GO terms across cancer lineages are Negative regulation of mRNA processing, Positive regulation of DNA repair, and Mitochondrial transport. Each is linked with BEST4 in more than 20 cancer types. Because this analysis shows association rather than direction, both BEST4-to-partner and partner-to-BEST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA processing grouped by BEST4-low versus BEST4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST4→partner) and Y-score (partner→BEST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of mRNA processing →	+0.047	+0.347	<.001	<.001	3	21
STAD	Positive regulation of DNA repair →	+0.040	+0.291	<.001	<.001	3	20
STAD	Mitochondrial transport →	+0.046	+0.359	<.001	<.001	3	20
ACC	Negative regulation of DNA-templated transcription, elongation →	+0.056	+0.725	<.001	.001	3	20
UVM	Intraciliary anterograde transport →	+0.052	+0.215	<.001	<.001	3	20
STAD	Peroxisome organization →	+0.043	+0.430	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,161 associations by consensus.

Negative regulation of mRNA processing by BEST4 expression — STAD

Explore this box plot interactively →