BEST4

Across TCGA pan-cancer cohorts, BEST4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of BEST4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where BEST4 RNA is repressed in tumor relative to normal tissue. In most cancer types BEST4 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KIRC, and KICH are the cancer types where BEST4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BEST4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−5.782	<.001	12	view →
KIRC	All	All	+0.872	<.001	11	view →
KICH	All	IV	−0.940	<.001	10	view →
THCA	All	II,III,IV	+0.524	<.001	8	view →
HNSC	Male	All	+0.456	<.001	8	view →
LIHC	Male	All	+0.326	<.001	8	view →
READ	Male	All	−5.846	<.001	7	view →
BLCA	All	All	+0.669	.005	5	view →
PAAD	All	All	+1.157	.013	4	view →
LUAD	All	All	+0.394	.001	4	view →
CHOL	Male	All	+0.921	<.001	2	view →
KIRP	All	All	+0.384	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

BEST4–COAD

Open the COAD breakdown →