BEST4

Across TCGA patient cohorts, BEST4 mutation is significantly associated with the RNA expression of many other genes, with 534 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEST4-associated genes across cancer lineages are CCDC137P, SYCE2, and LETM1. Each is linked with BEST4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEST4-to-partner and partner-to-BEST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC137P grouped by BEST4-low versus BEST4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST4→partner) and Y-score (partner→BEST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CCDC137P →	+0.062	+3.501	.002	.005	3	2
UCEC	SYCE2 →	+0.805	+3.617	<.001	.001	3	2
UCEC	LETM1 →	+0.574	+3.627	.001	.001	3	2
UCEC	NIPA1 →	+0.871	+3.606	.001	.001	3	2
UCEC	MIR3909 →	+0.430	+2.963	<.001	<.001	3	2
UCEC	NCR1 →	+0.520	+3.617	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 534 associations by consensus.

CCDC137P by BEST4 expression — SKCM

Explore this box plot interactively →