BEST4

Across TCGA patient cohorts, BEST4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEST4-associated genes across cancer lineages are XBP1, ATM, and 4E-BP1. Each is linked with BEST4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEST4-to-partner and partner-to-BEST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by BEST4-low versus BEST4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST4→partner) and Y-score (partner→BEST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XBP1 →	-0.243	-2.986	.001	.035	3	1
UCEC	ATM →	-0.807	-2.986	<.001	.035	3	1
UCEC	4E-BP1 →	+0.589	+2.837	<.001	.035	3	1
UCEC	eIF4E →	+0.259	+3.321	.019	.010	1	2
UCEC	TIGAR →	+0.169	+3.348	.034	.005	2	1
UCEC	ERK2 →	+0.265	+3.321	.008	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

XBP1 by BEST4 expression — UCEC

Explore this box plot interactively →