BEST4

Across TCGA cell cohorts, BEST4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,726 significant associations in total. CNS shows the largest number of these associations.

The most reproducible BEST4-associated GO terms across cancer lineages are Regulation of myoblast fusion, Viral genome replication, and Regulation of intracellular protein transport. Each is linked with BEST4 in more than 11 cancer types. Because this analysis shows association rather than direction, both BEST4-to-partner and partner-to-BEST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by BEST4-low versus BEST4-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST4→partner) and Y-score (partner→BEST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of myoblast fusion →	+0.082	+0.158	.004	<.001	2	12
UPPER_AERODIGESTIVE_TRACT	Viral genome replication →	+0.150	+0.426	<.001	.002	3	10
URINARY_TRACT	Regulation of intracellular protein transport →	+0.082	+0.405	<.001	<.001	3	10
BONE	Negative regulation of myoblast fusion →	+0.101	+0.107	<.001	<.001	3	10
BONE	Cilium or flagellum-dependent cell motility →	-0.084	-0.095	<.001	<.001	3	9
BONE	Regulation of intracellular transport →	+0.058	+0.075	.003	.006	1	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,726 associations by consensus.

Regulation of myoblast fusion by BEST4 expression — KIDNEY

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