BEST4

Across TCGA cell cohorts, BEST4 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BEST4-associated genes across cancer lineages are OR5C1, MSGN1, and BPIFB6. Each is linked with BEST4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEST4-to-partner and partner-to-BEST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5C1 grouped by BEST4-low versus BEST4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST4→partner) and Y-score (partner→BEST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR5C1 →	+0.050	+3.793	<.001	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.069	+3.930	.002	.003	3	1
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR2B2 →	+0.030	+4.347	.003	.001	3	1
LARGE_INTESTINE	OR2AT4 →	+0.018	+4.196	.001	.002	3	1
LARGE_INTESTINE	TFDP3 →	+0.022	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

OR5C1 by BEST4 expression — LARGE_INTESTINE

Explore this box plot interactively →