BEST2

Across TCGA patient cohorts, BEST2 RNA expression is significantly associated with the RNA expression of many other genes, with 10,630 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible BEST2-associated genes across cancer lineages are KCNJ14, MTND2P40, and SYCE2. Each is linked with BEST2 in more than 18 cancer types. Because this analysis shows association rather than direction, both BEST2-to-partner and partner-to-BEST2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BEST2 versus KCNJ14 in SCLC, with a Pearson correlation of 0.23.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST2→partner) and Y-score (partner→BEST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	KCNJ14 →	+1.038	+0.340	<.001	<.001	1	19
LAML	MTND2P40 →	+0.657	+0.299	<.001	<.001	3	16
SARC	SYCE2 →	+0.710	+0.099	<.001	<.001	3	16
CESC	RAPGEFL1 →	+1.211	+0.767	<.001	<.001	3	16
GBM	KCNAB3 →	+0.716	+0.165	<.001	<.001	3	16
CHOL	TMEM147-AS1 →	+0.985	+0.050	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,630 associations by consensus.

BEST2 vs KCNJ14 — SCLC

Explore this scatter interactively →