BEND7

Across TCGA patient cohorts, BEND7 mutation is significantly associated with the RNA expression of many other genes, with 2,116 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEND7-associated genes across cancer lineages are PSAT1P4, DNAJC8, and MED8. Each is linked with BEND7 in more than 3 cancer types. Because this analysis shows association rather than direction, both BEND7-to-partner and partner-to-BEND7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by BEND7-low versus BEND7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEND7→partner) and Y-score (partner→BEND7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSAT1P4 →	+0.106	+1.651	.002	<.001	3	4
UCEC	DNAJC8 →	+0.338	+1.914	<.001	<.001	3	3
SKCM	MED8 →	+0.395	+3.487	.005	.002	3	3
SKCM	C1orf50 →	+0.405	+2.732	<.001	.003	3	3
UCEC	TXLNA →	+0.307	+1.809	.001	.001	3	3
SKCM	RPA2 →	+0.447	+3.347	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,116 associations by consensus.

PSAT1P4 by BEND7 expression — UCEC

Explore this box plot interactively →