BEND7

Across TCGA cell cohorts, BEND7 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BEND7-associated genes across cancer lineages are TBL1Y, CLDN34, and SPINK9. Each is linked with BEND7 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEND7-to-partner and partner-to-BEND7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBL1Y grouped by BEND7-low versus BEND7-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEND7→partner) and Y-score (partner→BEND7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TBL1Y →	+0.005	+4.614	<.001	.004	3	1
BLOOD_Myeloma	CLDN34 →	+0.043	+4.807	<.001	.006	3	1
CNS	SPINK9 →	+0.078	+5.321	<.001	.005	3	1
LARGE_INTESTINE	KCTD8 →	+0.149	+4.510	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TBL1Y by BEND7 expression — PANCREAS

Explore this box plot interactively →