BEND3

Across TCGA cell cohorts, BEND3 mutation is significantly associated with the RNA expression of many other genes, with 518 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BEND3-associated genes across cancer lineages are ZIC5, COQ7, and THAP9. Each is linked with BEND3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEND3-to-partner and partner-to-BEND3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC5 grouped by BEND3-low versus BEND3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEND3→partner) and Y-score (partner→BEND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZIC5 →	+1.186	+3.459	<.001	.001	3	2
LARGE_INTESTINE	COQ7 →	+0.493	+3.169	<.001	.006	3	2
BLOOD_Leukemia	THAP9 →	+0.772	+3.259	<.001	.006	3	2
BLOOD_Leukemia	USP38 →	+0.729	+3.259	<.001	.006	3	2
BLOOD_Leukemia	POU3F3 →	+0.541	+2.760	.006	.004	3	2
LARGE_INTESTINE	VSIR →	-1.215	-2.657	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 518 associations by consensus.

ZIC5 by BEND3 expression — LARGE_INTESTINE

Explore this box plot interactively →